ceesdekker.net - An Overview
ceesdekker.net - An Overview
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‘The second is nanopores, that is our oldest line of analysis and which has now led to DNA sequencers based on nanopores. We pull personal DNA strands via a nanopore and might then study from the nucleotide sequence. Very not long ago, we even managed to read out a single protein for The 1st time applying This method. But this line of analysis is not merely about establishing tools, but in addition about actual biological thoughts.
It absolutely was only inside the nineteen nineties although, when nanotechnology experienced Sophisticated to your level the place one molecules could possibly be manipulated, that the main experimental units commenced to appear.
‘It had been just a make a difference of picking up a reserve on mobile biology and starting to go through. I had originate from a entire world of ultra-high vacuums, cryostats and quantum phenomena, and now I had been Doing work at space temperature with molecular biology kits.
Deposition and atomic pressure microscopy of particular person phthalocyanine polymers amongst nanofabricated electrodes
We produce position-of-treatment diagnostics take a look at of neglected tropical disorders inside of resource-confined options, depending on Crspr/Cas9 detecting of pathogen’s DNA in physique fluids.
Case in point (3) of bending configurations in 3D simulations of DNA rods on nanopores. A percentage of the membrane is demonstrated in grey, the rim from the pore is highlighted in purple, as well as a 3D rendering from the movement on the DNA rod is displayed.
Due to the fact 2000 he moved to solitary-molecule biophysics and nanobiology, with study from DNA supercoiling studies of nucleosomes and DNA maintenance proteins to DNA translocation as a result of nanopores. Not long ago his investigation has focused on researching cell division with bacteria on chip, though his best fascination is inside the direction of noticing synthetic cells.
Atomic power microscopy displays that vaccinia topoisomerase IB generates filaments on DNA inside of a cooperative style
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‘The fantastically refined way through which aspects in nature function never ceases to amaze me. If we address the puzzle of how lifetime came into becoming, I expect that my amazement within the complexity of generation could have greater and with it my awe to the greatness from the Creator.’
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Cees Dekker is Distinguished College Professor at TU Delft. Qualified for a physicist, he pioneered nanotechnology with quite a few discoveries on carbon nanotubes from the nineteen nineties. Due to the fact 2000, he moved to one-molecule biophysics and nanobiology. His latest investigation concentrates on (i) nanopores for protein sequencing; (ii) chromosome construction, particularly SMC motor protein; and (iii) building a living artificial mobile from lifeless molecules. Dekker is undoubtedly an elected member on the KNAW and fellow for the APS as well as the IOP.
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Illustration (2) of ceesdekker bending configurations in 3D simulations of DNA rods on nanopores. A part of the membrane is shown in grey, the rim of the pore is highlighted in purple, along with a 3D rendering with the motion on the DNA rod is displayed.